4. 4. 5. Zone of Calcified Cartilage Articular cartilage progenitor cells (ACPCs) usually exist in one third of the superficial zone of articular cartilage. Articular Cartilage Progenitor Cells. only a few cells thick and consists mostly of chondrocytes thst are dead because the ECM around them has calcified. . This preview shows page 121 - 125 out of 225 pages.. c. Zone of Hypertrophic cartilage ο extremely large chrondrocytes that are arranged in columns, ο maturing cells. Narrow zone of cartilage only a few cells thick B. 1)zone of reserve cartilage, 2)proliferation, 3)maturation, 4)hypertrophy, 5)degeneration, 6)ossification Definition list the zones in the epiphyseal plate (6-in order epiphysis to diaphysis) . Minerals deposited in the matrix between lacunae columns. Describe the zone of resting cartilage in the epiphyseal plate? Zone of calcified cartilage A. Metaphyseal (osteogenic) zone . this layer consists of large, maturing chondrocytes arranged in columns. .hypertrophied chondrocytes dying or lysed away, matrix material calcified, invasion of capillaries osteogenic cells. Blood vessel invasion was almost completely suppressed, concomitant with impaired trabecular bone formation and expansion of hypertrophic chondrocyte zone. Once cartilage cannot grow further, the structure cannot elongate more. d. Zone of calcified cartilage ο only a few cells thick, ο ο only a few cells thick, ο On the diaphyseal side of the growth plate, cartilage calcifies and dies, then is replaced by bone (figure 6.43, zones of hypertrophy and maturation, calcification and ossification). Recruitment and/or differentiation of chondroclasts, which express gelatinase B/matrix metalloproteinase-9, and resorption of terminal chondrocytes decreased. hyaline cartilage anchors growth plate to bone. (calcification kills chondrocytes and matrix appears opaque). Articular cartilage can be divided into four zones depending on the collagen and proteoglycan organization and content: the superficial zone, the transitional zone, the middle (radial) or deep zone, and the calcified cartilage zone (Fig. B. Lacunae walls become thin as the chondrocytes resorb matrix during hypotrophy. As cartilage grows, the entire structure grows in length and then is turned into bone. 1. zone of resting cartilage 2. zone of proliferating cartilage 3. zone of hypertrophic cartilage 4. zone of calcified cartilage. EXTRACELLULAR MATRIX OF BONE OSTEOID - MIXTURE OF TYPE I COLLAGEN AND COMPLEX MATRIX MATERIAL TO INCREASE THE AFFINITY AND SERVE AS NUCLEATION SITES 3. . 3. Zone of hypertrophic cartilage. cell division ceases, chondrocytes increase in size. Zone of resting/ reserve cartilage Zone of proliferation Zone of hypertrophy Zone of ossification Zone of calcification bone . . Zone of maturing cartilage . Zone of Hypertrophic Cartilage a. 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